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GLP-1 Drugs Could Raise the Risk of Weaker Bones and Gout

DJ-1 (PARK7), a multifunctional protein associated with early-onset Parkinson’s disease (PD) and elevated in cancers, stabilizes Nrf2 by interfering with Nrf2-Keap1 binding to protect against oxidative stress in dopaminergic neurons and cancer cells (72)

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A popular approach involves 6 weeks of daily administration followed by 2 weeks off, repeated throughout the year